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Grape seed

Grapes are native to Asia near the Caspian Sea, but were brought to North America and Europe around the 1600s. This plant's climbing vine has large, jagged leaves, and its stem bark tends to peel. The grapes may be green, red, or purple.
Among other beneficial effects, the active compounds in grape seed {Grape Seed Oil, Grape Seed Extract, muskat) are believed to have antioxidant properties. In fact, a recent study of healthy volunteers found that supplementation with grape seed extract substantially increased levels of antioxidants in the blood. Antioxidants are substances that destroy free radicals {damaging compounds in the body that alter cell membranes, tamper with DNA (genetic material), and even cause cell death}.
Today, Naturopathic health care professionals use standardized extracts of grape seed to treat a range of health problems related to free radical damage, including blood sugar regulation problems, heart disease, and cancer. Studies in laboratories, animals, and people lend some support to these uses.
Flavonoids found in red wine have been reported to protect the heart. They may inhibit the oxidation of LDL ("bad") cholesterol. (LDL oxidation which can lead to hardening of the arteries or atherosclerosis). Studies have demonstrated a relationship between flavonoid intake (from foods) and reduced risk of death from coronary heart disease.
The Mediterranean diet is comprised of whole grains, fresh fruits and vegetables, fish, olive oil, and moderate, daily wine consumption. In a long-term study of 423 patients who suffered a heart attack, those who followed a Mediterranean diet had a 50 - 70% lower risk of recurrent heart disease compared with controls who received no special dietary counseling. Some researchers believe that some of the beneficial effects of the Mediterranean diet are due to flavonoids found in red wine. (Another well-known theory along these lines is called "The French Paradox." The belief is that drinking wine protects those living in France from developing heart disease at as high a rate as those living in the United States, despite the rich fatty foods they eat.)
Others speculate that the healthful effects of moderate wine consumption are due to its alcohol content and not its flavonoid content. If the flavonoids are contributing to heart protection, then grape seed extracts offer an important alternative to alcohol, particularly given the down sides of drinking alcohol (see below). A third concept is being proposed by a group of researchers who believe that the beneficial effects of wine may be triggered by a complex interaction of alcohol and flavonoids. As the controversy of which ingredient in wine is the most important continues, both grape seed extracts and red wine continue to be promoted for heart health. In addition, several test tube and animal studies confirm that antioxidants from grapes offer cardioprotection in their own right.
It is also important to note that the use of alcohol is not advocated by the American Heart Association and other organizations because of the potential for addiction and the other serious repercussions, such as motor vehicle accidents and the development of hypertension, liver disease, breast cancer, and weight gain. If you do drink red wine, you should have no more than 2 glasses (20 g ethanol) per day.

Proported Uses

• Atherosclerosis
• Burns
• Cancer prevention
• Constipation
• GI disorders
• High cholesterol
• Wound healing

Mechanism of Action

Vitamin E, flavonoids, linoleic acid, and compounds called procyanidins {also known as condensed tannins, pycnogenols, and oligomeric proanthocyanidins or OPCs} are highly concentrated in grape seeds. These healthful compounds can also be found in lower concentrations in the skin of the grape. Procyanidins are also found in grape juice and wine, but in lower concentrations.
Procyanidins, subunits of proanthocyanidins, from V. vinifera seeds have been shown to have antioxidant activity and to alter capillary permeability in animal models. GPSE has protective effects on doxorubin-induced cardiotoxicity. Cardioprotective effects theoretically come from its ability to modulate anti-apoptotic genes and modify molecular targets such as DNA damage and repair, lipid peroxidation and intracellular calcium homeostasis.
Procyanidins also inhibit xanthine oxidase activity and non-competitively inhibit the proteolytic enzymes collagenase and elastase and the glycosidases hyaluronidase and beta-glucuronidase. Polyphenolic substances from grape seeds have been shown to inhibit the growth of Streptococcus mutans and glucan formation from sucrose, which may aid in the prevention of dental caries. Seed tannins may stimulate cell renewal by interfering with mucosal proteins. Resveratrol is another of grape's healthful compounds which are related to procyanidins and found mainly in the skins.
Free radicals occur naturally in the body, but environmental toxins (including ultraviolet light, radiation, smoke, certain prescription and non-prescription drugs, and air pollution) can also increase the number of these damaging particles. Free radicals are believed to contribute to the aging process as well as the development of a number of health problems, including heart disease and cancer. Antioxidants found in grape seeds can neutralize free radicals and may reduce or even help prevent some of the damage they cause.
Resveratrol has gained much popularity as an antioxidant supplement

Adverse Reactions

Reported: None.

Interactions

Cytochrome P450: Grape seed extract has been shown to inhibit cytochrome P450 isoenzymes, therefore may affect serum concentrations of certain medications metabolized by the same enzyme. Warfarin (Coumadin): due to its tocopherol content, GSE may theoretically enhance the activity of warfarin

Clinical Summary

Obtained as a by-product of wine production, grape seeds are ground to produce grape seed oil. Anecdotally, grape seed oil and grape seed extract (GSE) have been used as a laxative, antacid, cholagogic agent, in treating burns, ulcers, and as a hand cleanser. Studies of grape seed proanthocyanidin extract (GSPE) in mice have shown effectiveness in minimizing doxorubicin-induced cardiotoxicity as well as other drug-induced nephrotoxicity, pulmonary toxicity.
In vitro studies have shown GSPE to have synergistic anti-cancer effects with doxorubicin. GSPE also inhibits atherosclerosis. Small human trials have shown possible efficacy in decreasing LDL and increasing total serum antioxidant activity. Additionally, topical application of GSPE has been shown to accelerate wound contraction and closure. But orally administered GSPE was not effective for breast induration following radiotherapy in patients with breast cancer.
No side effects have been reported for GSPE consumption, however, because of its interference with cytochrome P450, it may affect the metabolism of certain drugs.

References

1. DerMarderosian A. The Review of Natural Products. St. Louis: Facts and Comparisons, 1999.
2. Bombardelli E,.Morazzoni P. Vitis vinifera L. Fitoterapia 1995;66:291-317.
3. Ray SD, Patel D, Wong V, Bagchi D. In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Res Commun. Mol. Pathol. Pharmacol. 2000;107:137-66.
4. Yu H, Wang SE, Zhao C, Xu G. [Study of anti-atherosclerosic effect of grape seed extract and its mechanism]. Wei Sheng Yan. Jiu. 2002;31:263-5.
5. Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG et al. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat. Res 2003;523-524:87-97.
6. Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med 2000;31:227-46.
7. Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm. Ther. 1998;23:385-9.
8. Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D et al. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic. Biol Med 2002;33:1089-96.
9. Bentivegna SS,.Whitney KM. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food Chem. Toxicol. 2002;40:1731-43.
10. Yamakoshi J, Saito M, Kataoka S, Kikuchi M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem. Toxicol. 2002;40:599-607.
11. Kim JM,.White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol. 1996;77:545-6.
12. Corrigan JJ, Jr.,.Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1.
13. Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004;85:1-12.
14. Brooker S, Martin S, Pearson A, et al. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother Oncol. 2006;79(1):45-51.
    

Disclaimer:
These statements have not been evaluated by the FDA. Any product mentioned is not intended to diagnose, treat, cure or prevent any disease.

Credit: Source 

"Introducing PHYTOSCIENCE DOUBLE STEM CELL..

HOW YOU CAN AFFORD TO 'MAINTAIN' HEALTHY, BEAUTIFUL & with YOUTHFULNESS  ... 

     NO Need 'Waste Ur Money' each month at  Beauty Parlour Or Make Surgery To Staying Young ...      

want to keep looking Young , HEALTHY & with YOUTHFULNESS as they are ???

 "Yes, the above statement is true. Not a mere fraud. If you've tried all sorts of techniques for beautiful and youthful looks but still fail, there is still hope for you. Please READ so exhausted because I will reveal to you a more convenient and proven effective for the solution of your problems ...

"Introducing PHYTOSCIENCE DOUBLE STEM CELL..

WHAT is PhytoScience Double Stem cell???

Double Stem Cell Product

Dear Friends, 

Today, enhancing the body's immune system is important in order to extend the life of your person. The majority believe a balanced diet help maintain health. But, how many people understand the meaning of a balanced diet? Please reflect, ponder the facts below: 

Did you know there are over 75,000 synthetic chemicals in our environment today? These chemicals have never existed before 1940 

• Fruits now not enough nutrients because he had not yet ripe, it is harvested 
• Even the use of pesticides in fruits and vegetables have an impact on the nutritional content 
• For dairy products such as chicken and beef, antibiotics and growth hormones are used to accelerate the 
• Not forgetting processed foods with preservatives, artificial flavors and artificial colors.

Did you believe  that can still  follow the balanced diet ?

What makes this product PhytoScience Double StemCell different from the others?

 Yes, as I said earlier there are four main ingredients in this product :

• Stem Cell from Swiss Apples (Uttwiler Spattauber)

Uttwiler Spattauber is the scientific name for apple trees from Switzerland. Grown since the beginning of the 18th century. Able to repair itself quickly if the tree or the fruit injured and able to last longer than other types. It is close to extinction because of its sour fruit and making it less crowded. 0.1% of PhytoCellTec ™ is capable of generating up to 80% of stem cells in the human body. This is evidenced by research from a team of scientists at Mibelle Biochemistry. This is the secret formula that makes the product unique Phytoscience Double Stem Cell compared to other products. 

Apple is not the same kind and hard to find in the supermarket near you. It has a high antioxidant. The proof will not rotten apples or shrink when falling to the ground in a long time; between 4 to 6 months. 

Let's see how PhytoCellTec ™ MalusDomestica (Apple Stem Cell) acts on cells of the skin:

• Stem Cells from Grapes

Stem Cell from Gamay grapes Teinturier Freaux. Originally from Burgundy, France. High antioxidant and a free radical exclusion that serves as a protective agent against UV. 

Skin is kept moist and become more supple and soft because this wine stimulates new cells to grow continuously as well as improving of skin cells damaged.

• Acai Berry

Acai Berry is considered the "Beauty Berry from the Amazon." 

Acai Berry contains a variety of nutrients. Among the flavonoids and anthocyanins which help generate more antioxidants than regular berries. Antioxidant rate is 5 times higher than gingko and 3 three times higher than red wine. Acai Berry also contains Amino Acids, Omega, Vitamin A, Vitamin B1, Vitamin E, fatty acids and some other natural minerals. 

Other Benefits of Acai Berry: 

> Helps reduce body weight by increasing metabolism as well as remove toxins from the body 

> Help your body get the quality of a good rest and give enough energy during the day 

> Strengthen memory and concentration as well as blood circulation 

> Lowers cholesterol and strengthens the function of the heart.

• Blueberry

Blueberries are loaded with nutrients such as minerals, vitamins, and antioxidants. Among the characteristics of Blueberries: 

>Able to reduce the fat, and stabilize insulin levels in the body. It can also help to prevent cancer as well as health oskular and eliminate free radicals 

Blueberries are rich in vitamin C, which helps build the immune system is high It also contains iron, Vitamin A, Vitamin E, Vitamin K, Magnesium, Calcium, Selenium, Zinc and Phosphorus 

Blueberries help maintain healthy vision and the retina of your eyes 

Blueberry able to mengurangkanberat body and prevent heart disease 

Blueberries contain flavonoids that can strengthen memory and cognitive functions, such as maintaining understanding, decision-making and the ability to analyze 

Flavonoids in blueberries also help prevent diseases such as Parkinson's and Alzheimer's. Content of flavonoids found in blueberries also help slow down the mental aging process 

Antioxidants in Blueberry mamapu slow the aging process and to treat diabetes and high blood pressure. It also can prevent cervical cancer and breast cancer as well as infections of the urinary tract problems

Oh, Yes! PhytoScience Double Stem Cell is highly recommended for those of you who suffer from diseases such as the following:

• Way of eating double stem cell

With nanotechnology, it is very easy and quick to absorb. No need to mix with water first. Just put it under the tongue alone is sufficient! 

Double Stem Cell

14 sachets x 1200mg (1 box) 

Dosage: 1 sachet per day 

What is the actual price for this Unique Product? 

Your small investment in the health and youthfulness of the skin are as follows:

Quite cheap when compared to the value of any treatment and surgery available in the market now. 

Now Everyone Can Have A Healthy Body, Beautiful Charming With Cheaper Cost. TRY IT YOURSELF AND IMPACT OF NUTRITION Stem Cell Double PhytoCell today for the SIGNIFICANT ...! 

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KEBAIKAN PENGAMBILAN PHYTOSCIENCE DOUBLE STEMCELL

PhytoCellTec™ MalusDomestica (Apple Stem Cell)
Diambil dari buah Apple Uttwiller Spatlauber, direkodkan sejak abad ke 18 dijumpai di Thurgau, daerah Utara Switzerland. Buah Apple jenis ini sangat popular kerana boleh disimpan lama. Kelihatan segar walaupun setelah lebih 4 bulan di petik. Lebih lama dari Apple lain yang kelihatan kecut dan berkedut. kulit pokoknya juga akan cepat pulih sekiranya tercedera. Khasiat Stem Cell dari buah Apple jenis ini adalah melambatkan proses PENUAAN (anti – ageing), melindungi dan mempercepatkan pertumbuhan sel kulit baru dan melambatkan kedutan. Antara artis yang menggunakan teknologi Apple Stem Cell ini adalah Michelle Obama dan Jennifer Lopez.

                                                                                     

  

Apa itu Sel Stem, dan mengapa ianya penting?
Sel Stem mempunyai potensi yang luar biasa untuk berkembang menjadi pelbagai jenis sel yang berbeza dalam tubuh pada awal kehidupan dan pertumbuhannya. Sel Stem boleh di anggap sebagai sistem pembaikan dalaman, membahagi tanpa batas untuk mengisi sel-sel yang rosak selama seseorang itu masih hidup. Ketika sebuah Sel Stem berbahagi, setiap sel baru mempunyai potensi untuk menjadi stem cell atau menjadi sel jenis lain dengan fungsi yang lebih khusus, seperti sel otot, sel darah merah, sel otak, sel jantung dan lain-lain.
Bagaimanakah pertambahan jumlah sel stem yang beredar di dalam badan boleh mendorong kepada kesihatan yang optimum?

Sel stem yang beredar boleh sampai kepada pelbagai organ dan menjadi sel kepada organ tersebut, membantu organ tersebut untuk mendapatkan semula dan mengekalkan kesihatan yang optimum. Kajian baru-baru ini telah mencadangkan bahawa jumlah sel stem yang beredar di dalam badan adalah kunci utama; semakin banyak jumlah sel stem yang beredar, semakin bagus keupayaan diri untuk memulihkan dirinya sendiri.

Mengapa sel stem penting untuk kesihatan?

Apabila kita tercedera atau sakit, sel-sel dalam badan kita turut tercedera malah mungkin mati. Pada masa ini, sel-sel stem akan diaktifkan. Sel-sel stem berfungsi untuk memperbaiki tisu badan yang rosak dan menggantikan sel-sel yang mati. Dengan berbuat demikian, sel-sel stem menyihatkan badan kita dan mencegah penuaan awal. Sel-sel stem boleh diibaratkan sebagai pasukan perubatan mikro dalam badan kita demi mencapai fungsi-fungsi terapi semula jadi, anti penuaan dan kecantikan.

Bagaimanakah pertambahan jumlah sel stem yang beredar di dalam badan boleh mendorong kepada kesihatan yang optimum?

Sel stem yang beredar boleh sampai kepada pelbagai organ dan menjadi sel kepada organ tersebut, membantu organ tersebut untuk mendapatkan semula dan mengekalkan kesihatan yang optimum. Kajian baru-baru ini telah mencadangkan bahawa jumlah sel stem yang beredar di dalam badan adalah kunci utama; semakin banyak jumlah sel stem yang beredar, semakin bagus keupayaan diri untuk memulihkan dirinya sendiri.

Berapa kerapkah tisu diperbaharui?

Sel-sel tubuh sentiasa ditukar ganti, bermaksud sel-sel akan mati dan digantikan dengan sel-sel yang baru bagi menjana pembaharuan tisu. Sebagai contoh: Pembaharuan sepenuhnya tisu-tisu anda berlaku mengikut tempoh masa yang tertentu: 

Lapisan usus – setiap 5 hari

Sel darah merah – setiap 90 hari

Sel darah merah - setiap 90 hari
Hati – setiap 3 tahun
Paru-paru – setiap 4-5 tahun
Jantung – setiap 20-25 tahun

KEBAIKAN PENGAMBILAN DOUBLE STEMCELL

1) Membantu mengurangkan kedutan pada kulit terutama kulit muka.
2) Membantu menguatkan sendi dan tulang.
3) Mengaktifkan sel-sel badan dan kulit.
4) Membantu bertindak sebagai anti penuaan dan antioksidan untuk menjaga kesihatan dan jantung.
5) Mengurangkan risiko kanser.
6) Membantu menigkatkan daya penyerapan kolagen oleh badan.
7) Membantu merangsang badan bagi menghasilkan lebih banyak kolagen tersendiri.
Membantu menjadikan kulit gebu, halus, licin, anjal dan menjaga kelembapan kulit agar kulit sentiasa segar dan bermaya.
9) Melindungi kulit daripada terkena cahaya UV berlebihan yang boleh merosakkan sel-sel kulit.

Kandungannya anda dah tahu, kebaikan pengambilannya pun anda dah tahu…jom sekarang ini kita tengok pula siapa yang perlu mencuba serta menggunakannya.

Amatlah disyorkan kepada mereka yang mempunyai masalah seperti berikut:
•Gout
•Kencing manis
•Darah tinggi
•Lemak darah
•Anemia
•Kulit sensitif
•Sistem penghadaman lemah
•Demam selsema
•Mudah letih dan badan lemah
•Tekanan
•Kolestrol tinggi

Bagaimana cara penyediaan Double Stemcell ini?

14 sachets X 1200mg (1 Kotak)
Pengambilan: 1 sachet setiap hari
Dengan teknologi nano, ia amat mudah dan cepat untuk diserap. Hanya letakkan di bawah lidah sahaja sudah memadai tanpa perlu dicampurkan dengan air terlebih dahulu.

Sekali lagi saya ringkaskan Ramuan Utama Double StemCell ini:

1) Sel Stem Epal Phytocelltec™
Meransang Sel Stem, mengaktifkan Sel Stem badan, kuasa pemulihan dan kuasa pemutaran.
2) Sel Stem Anggur Phytocelltec™
Meransang Sel Stem, mengaktifkan Sel Stem badan dan melindungi Sel Stem dari sinaran UV.

3) Acai Berry
Ia bukan sahaja antioksidan, ianya juga padat dengan asid lemak omega, asid amino, mineral semulajadi serta Vitamin A, B1 dan E.

4) Beri Biru ( Blueberry)
Penggunaan untuk anti penuaan, kencing manis, keletihan mata, menentang kanser serviks/payu dara, perlindungan sistem jantung, peningkatan selera makan, peningkatan daya ingatan, menyokong saluran darah, mengelak daripada jangkitan saluran air kencing dan juga pengurangan kolestrol dalam badan.

(Semenanjung Malaysia RM270, Sabah&Sarawak Rm285)

Harganya dah saya dedahkan…untung runcit berbaloi2...yang bakal menjadikan impian anda suatu kenyataan dengan hanya mengamalkan produk ini… Nak tak? ni saya khaskan hanya pada anda yang betul2 minat bisnes dan yang yakin anda akan berjaya. Untuk rakan-rakan yang memang terlibat dalam bisnes kecantikan atau saloon, amatlah dialu-alukan. So, sesiapa yang mempunyai ciri2 yang saya cari ni. Jika anda ingin membeli produk ini klik di sini untuk mengisi borang https://docs.google.com/forms/d/1LS4r8oDJ_TDYUtU_BAa-LPy4APJdjuGuZdgjXoLIxcw/viewform

Percayakah anda jika saya katakan anda akan dapat RM100 bila ada rakan anda beli produk PhytoScience Double StemCell ini yang berharga RM270? Gila kan…ya memang gila..tapi itulah yang akan anda dapat jika anda menyertai kami… Jadi, tunggu apa lagi..ni baru satu ‘kegilaan’ yang saya dedahkan..ada banyak lagi..

Dan klik di sini jika ingin menjadi agent